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CD4 and LAG-3 from sharks to humans: related molecules with motifs for opposing functions. Frontiers in Immunology, 14, Article 1267743
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An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution. Molecular Biology and Evolution, 40(12), Article msad262
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Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks. Immunogenetics, 73(1), 17–33
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A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage. Journal of Immunology, 207(3), 824–836
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Nurse shark T-cell receptors employ somatic hypermutation preferentially to alter alpha/delta variable segments associated with alpha constant region. European Journal of Immunology, 50(9), 1307–1320
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An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish. Journal of Immunology, 204(4), 892–902
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Feng, M. & Bian, H. & Wu, X. & Fu, T. & Fu, Y. & Hong, J. & Fleming, B.D. & Flajnik, M.F. & Ho, M. (2019)
Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks. Antibody Therapeutics, 2(1), 1–11
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Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus. eLife, 7, Article e28477
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Elephant shark genome provides unique insights into gnathostome evolution. Nature, 505, 174–179
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Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny. European Journal of Immunology, 43(11), 3061–3075
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Smith, L.E. & Crouch, K. & Cao, W. & Müller, M.R. & Wu, L. & Steven, J. & Lee, M. & Liang, M. & Flajnik, M.F. & Shih, H.H. & Barelle, C.J. & Paulsen, J. & Gill, D.S. & Dooley, H. (2012)
Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias). Developmental and Comparative Immunology, 36(4), 665–679
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Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II. Developmental and Comparative Immunology, 36(3), 521–533
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Marancik, D.P. & Leary, J.H. & Fast, M.M. & Flajnik, M.F. & Camus, A.C. (2012)
Humoral response of captive zebra sharks Stegostoma fasciatum to salivary gland proteins of the leech Branchellion torpedinis. Fish & Shellfish Immunology, 33(4), 1000–1007
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The Multiple Shark Ig H Chain Genes Rearrange and Hypermutate Autonomously. Journal of Immunology, 187(5), 2492–2501
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The generation and selection of single-domain, v region libraries from nurse sharks. Methods in Molecular Biology, 562, 71–82
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Immunoglobulin Heavy Chain Exclusion in the Shark. PLoS Biology, 6(6), Article e157
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Maturation of Shark Single-domain (IgNAR) Antibodies: Evidence for Induced-fit Binding. Journal of Molecular Biology, 367(2), 358–372
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Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey. BMC Genomics, 7, Article 106
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Antibody repertoire development in cartilaginous fish. Developmental and Comparative Immunology, 30(1–2), 43–56
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Histology and Immunology of the Placenta in the Atlantic Sharpnose Shark, Rhizoprionodon terraenovae. Placenta, 27(11), 1114–1123
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Immunoglobulins in the eggs of the nurse shark, Ginglymostoma cirratum. Developmental and Comparative Immunology, 29(5), 417–430
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Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum. European Journal of Immunology, 35(3), 936–945
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Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish. Journal of Immunology, 173(2), 1129–1139
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Homologs of CD83 from elasmobranch and teleost fish. Journal of Immunology, 173(7), 4553–4560
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Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display. Molecular Immunology, 40(1), 25–33
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Proteasome, transporter associated with antigen processing, and class I genes in the nurse shark Ginglymostoma cirratum: evidence for a stable class I region and MHC haplotype lineages. Journal of Immunology, 168(2), 771–781
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The development of primary and secondary lymphoid tissues in the nurse shark Ginglymostoma cirratum: B-cell zones precede dendritic cell immigration and T-cell zone formation during ontogeny of the spleen. Scandinavian Journal of Immunology, 56(2), 130–148
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A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG. Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1775–1780
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Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci. Immunogenetics, 49(11–12), 981–986
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Identification of class I genes in cartilaginous fish, the most ancient group of vertebrates displaying an adaptive immune response. Journal of Immunology, 159(12), 6097–6104
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A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks. Nature, 374(6518), 168–173
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Nucleotide sequence of a nurse shark immunoglobulin heavy chain cDNA clone. Molecular Immunology, 29(9), 1157–1158
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